3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt)

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Names and Identifiers

Name	Tropicamide
Synonyms	Mydrum Mydrin Mydriat Ro1-7683 Mydriacyl Epitromina Tropicamid Tropicamide TROPICAMIDUM Visumidriatic Tropicamide (200 mg) Component Of Paremyd Tropicamide for peak identification N-Ethyl-N-(4-Pyridylmethyl)Tropamide n-ethyl-2-phenyl-n-(4-pyridylmethyl)-hydracrylamid N-Ethyl-2-Phenyl-N-(4-Pyridylmethyl)-Hydracrylamid N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridinylmethyl)Propanamide N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide N-Ethyl-3-Hydroxy-2-Phenyl-N-(4-Pyridinylmethyl)Propanamide N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide N-Ethyl-3-Hydroxy-2-Phenyl-N-Pyridin-4-Ylmethyl-Propionamide (2R)-N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide (2R)-N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide (2S)-N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamide n-ethyl-alpha-(hydroxymethyl)-n-(4-pyridinylmethyl)-benzeneacetamid N-Ethyl-Alpha-(Hydroxymethyl)-N-(4-Pyridinylmethyl)-Benzeneacetamid TropicaMide N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylMethyl)propanaMide 3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) N-Ethyl-3-Hydroxy-2-Phenyl-N-(Pyridin-4-Ylmethyl)Propanamidebenzeneacetamide, N-Ethyl-Alpha-(Hydroxymethyl)-N-(4-Pyridinylmethyl)- Bistropamide
CAS	1508-75-4
EINECS	216-140-2
InChI	InChI=1/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3/t16-/m1/s1

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Physico-chemical Properties

Molecular Formula	C17H20N2O2
Molar Mass	284.35
Density	1.161±0.06 g/cm3(Predicted)
Melting Point	98 °C
Boling Point	492.8±45.0 °C(Predicted)
Flash Point	251.8°C
Water Solubility	0.2g/L(25 ºC)
Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.3mg/mL
Vapor Presure	1.58E-10mmHg at 25°C
Appearance	solid
Color	white
Maximum wavelength(λmax)	['254nm(HCl aq.)(lit.)']
Merck	14,9780
pKa	pKa 5.3 (Uncertain)
Storage Condition	2-8°C
Refractive Index	1.586
Use	Used as an anticholinergic, mydriatic agent

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
RTECS	CY1487860
HS Code	29333990

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Standard

Authoritative Data Verified Data

This product is n-ethyl-2-phenyl-n-(4-pyridylmethyl) hydroxypropionamide. Calculated as dried product, the content of C17H20N202 shall not be less than 98.5%.

Last Update：2024-01-02 23:10:35

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Trait

Authoritative Data Verified Data

This product is white crystalline powder; Odorless.
This product is soluble in ethanol or chloroform, slightly soluble in water; Soluble in dilute hydrochloric acid or dilute sulfuric acid.

melting point

The melting point of this product (General 0612) is 96~100°C.

absorption coefficient

take this product, precision weighing, add 0.05mol/L sulfuric acid solution to dissolve and quantitatively dilute to make a solution containing about 25ug per 1 ml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General Rule 167), and the absorption coefficient was 177.

Last Update：2022-01-01 11:44:36

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Differential diagnosis

Authoritative Data Verified Data

take about 5mg of this product, add 1 ml of ethanol to dissolve, add 2, 4-dinitrochlorobenzene 0.lg, put it on a water bath and heat it for 5 minutes, let it cool, add 1 ml of sodium hydroxide ethanol solution (l-100), the solution was red and purple.
take this product, add 0.1 mol/L sulfuric acid solution is made into a solution containing about 25ug per 1 ml, which is determined by ultraviolet-visible spectrophotometry (General rule 0401), and is in the wavelength range of 220 ~ 350nm, there is a maximum absorption only at a wavelength of 254mn.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 746).

Last Update：2022-01-01 11:44:37

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Exam

Authoritative Data Verified Data

optical rotation

take about 2.5g of this product, put it in a 25ml measuring flask, add ethanol to dissolve and dilute to the scale, shake well, and determine it according to law (General rule 0621), the optical rotation was -0.1 ° to +0.1 °.

pH

take 0.20g of this product, add 100ml of water to dissolve it, and then measure it according to law (General rule 0631). The pH value should be 6.5-8.0.

clarity of ethanol solution

take this product l.Og, add ethanol 10ml after dissolution, the solution should be clarified.

chloride

take 0.5g of this product, Add 10ml of ethanol to dissolve it, and check it according to law (General rule 0801). Compared with the control solution made of 5ml of standard sodium chloride solution, it should not be more concentrated (0.010%).

Related substances

take this product, add methylene chloride to dissolve and dilute to make a solution containing about 20mg per 1 ml as a test solution; Take an appropriate amount of precision, respectively diluted with dimethyl methane to contain 0.04mg and 0. A 1 mg solution was used as the Control Solutions (1) and (2). Weigh about 10 mg each of N-(4-pyridylmethyl) ethylamine (impurity I) and tropicamide in a 10ml measuring flask, add dichloromethane to dissolve and dilute to scale, shake well, take 1 ml accurately, put it in a 10ml measuring flask, dilute it to the scale with dichloromethane, and shake it well to serve as a control solution (3). According to the thin layer chromatography (General 0502) test, absorb the above four solutions of 10 u1, respectively, on the same silica gel GF254 thin layer plate, with dichloromethane-methanol-concentrated ammonia solution (190:10:1) for the development of the agent, expand, dry, set the UV light (254mn) under the inspection. The chromatogram of the control solution (3) should show two clear spots. Test solution such as impurity spots, respectively, compared with the control solution (1), (2) showed the main spot, there can be only one impurity spot color deeper than the control solution (1) the color of the main spot should not be deeper than the color of the main spot of the control solution (2), and other impurity spots should not be deeper than the main spot of the control solution (1). N-ethyl-methyl pyridinamine take 0.10g of this product, add 2ml of water, heat and dissolve, let cool, add 1 ml of acetaldehyde solution (1-20), shake, add 3~4 drops of sodium nitrosoferricyanide solution and 3~4 drops of sodium bicarbonate solution, shake, the solution should not show blue.

loss on drying

take l.Og of this product, put the phosphorus pentoxide dryer under reduced pressure and dry to constant weight, and the weight loss shall not exceed 0.3% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).

Last Update：2022-01-01 11:44:38

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Content determination

Authoritative Data Verified Data

take this product about 0.2g, precision weighing, add glacial acetic acid 25ml dissolved, add crystal violet indicator liquid 1 drop, with perchloric acid titration solution (0.1 mol/L titration to the solution showed blue-green, and the titration results were corrected by blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 28.44mg of C17H20NgO2.

Last Update：2022-01-01 11:44:38

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Category

Authoritative Data Verified Data

mydriatic drugs.

Last Update：2022-01-01 11:44:38

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:44:39

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Tropicamide Eye Drops

Authoritative Data Verified Data

This product contains tropicamide (C17H20N202) should be 90.0% to 110.0% of the label.
This product can add an appropriate amount of cosolvent and bacteriostatic agent.

trait

This product is colorless and clear liquid.

identification

take 1ml of this product, add 2, 4-dinitrochlorobenzene O. 1G, heated on a water bath for 5 minutes, let cool, and add 1ml of sodium hydroxide ethanol solution (l-100), the solution is red and purple.
in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
the sample solution under the content measurement item was taken and measured by ultraviolet-visible spectrophotometry (General rule 0401), and there was a maximum absorption at a wavelength of Nm.

examination

the pH value should be 5.0 to 7.0 (General 0631).
osmolality the osmolality ratio shall be 0632-0.9 as determined by osmolality measurement method (General 1.1).
others shall comply with the relevant provisions under Ophthalmic Preparations (General rule 0105).

Content determination

measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test using octanosilane-bonded silica as filler I. Methyl -0.01mol/L sodium octane sulfonate solution (55:45, pH adjusted to 3.0 with phosphoric acid) the detection wavelength was 254nm. Take the reference substance of methyl hydroxybenzoate, ethyl hydroxybenzoate and tropicamide respectively, add the mobile phase to dissolve and dilute to prepare the solution containing 15ug of methyl hydroxybenzoate, 15ug of ethyl hydroxybenzoate and 150ug of tropicamide in each 1ml, and inject 10ug into the liquid chromatograph with precise volume, record the chromatogram, the number of theoretical plate shall not be less than 3000 according to the peak of tropicamide, and the separation degree of tropicamide peak, methyl hydroxybenzoate peak and ethyl hydroxybenzoate peak shall meet the requirements.
determination of precision: take an appropriate amount of this product (about 15mg equivalent to tropicamide) and quantitatively dilute it with mobile phase to prepare a solution containing about 0.15mg of tropicamide per 1ml as a test solution, lOul was injected into the liquid chromatograph accurately, and the chromatogram was recorded. Another reference substance of tropicamide was determined by the same method, and the peak area was calculated according to the external standard method.

specification

(l)5ml:12.5mg (2)5ml:25mg (3)6ml:15mg (4)6ml:30mg

storage

sealed storage.

Last Update：2022-01-01 11:44:40

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt)

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Tropicamide Request for quotation
CAS: 1508-75-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Worldyang Chemical Co.,Ltd.

Product Name: Tropicamide Request for quotation
CAS: 1508-75-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Tropicamide Request for quotation
CAS: 1508-75-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Worldyang Chemical Co.,Ltd.

Product Name: Tropicamide Request for quotation
CAS: 1508-75-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

View History

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt)

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) Request for Quotation

Tropicamide

CAS: 1508-75-4

Molecular Formula: C17H20N2O2

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Names and Identifiers

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Physico-chemical Properties

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Risk and Safety

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Standard

Authoritative Data Verified Data

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Trait

Authoritative Data Verified Data

melting point

absorption coefficient

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Differential diagnosis

Authoritative Data Verified Data

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Exam

Authoritative Data Verified Data

optical rotation

pH

clarity of ethanol solution

chloride

Related substances

loss on drying

ignition residue

Heavy metals

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Content determination

Authoritative Data Verified Data

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Category

Authoritative Data Verified Data

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Storage

Authoritative Data Verified Data

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt) - Tropicamide Eye Drops

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

Supplier List

3-[[(4,5-Dihydro-1 H -Imidazol-2-Yl)Methyl](4-Methylphenyl)Amino]-,Monomethanesulfonate (Salt)